Table 3.
Relationship between milk fat globule‐epidermal growth factor factor 8 (MFG‐E8) expression and clinicopathological factors in 68 patients with esophageal squamous cell carcinoma treated with neoadjuvant chemotherapy (NAC)
| Patient characteristics | NAC+ | |||
|---|---|---|---|---|
| MFG‐E8 Low | MFG‐E8 High | P‐value | ||
| N = 41 (%) | N = 27 (%) | |||
| Age, years | ≤65 | 25 (36.8) | 18 (26.5) | .630 |
| >65 | 16 (23.5) | 9 (13.2) | ||
| Sex | Male | 34 (50.0) | 26 (38.2) | .090 |
| Female | 7 (10.3) | 1 (1.5) | ||
| Tumor location[Link] | Ut | 0 (0) | 6 (8.8) | .002 |
| Mt‐Lt | 41 (60.3) | 21 (30.9) | ||
| Tumor differentiation[Link] | Well‐Mod | 32 (47.1) | 18 (26.5) | .300 |
| Por | 9 (13.2) | 9 (13.2) | ||
| Tumor depth[Link] | pT1‐2 | 12 (17.7) | 7 (10.3) | .760 |
| pT3‐4 | 29 (42.7) | 20 (29.4) | ||
| Lymph node metastasis[Link] | pN0‐1 | 30 (44.1) | 11 (16.2) | .008 |
| pN2‐3 | 11 (16.2) | 16 (23.5) | ||
| Non‐regional lymph node metastasis[Link] | pM0 | 34 (50.0) | 16 (23.5) | .030 |
| pM1 | 7 (10.3) | 11 (16.2) | ||
| Tumor stage[Link] | pStageI‐II | 15 (22.0) | 6 (8.8) | .210 |
| pStageIII‐IV | 26 (38.2) | 21 (31.0) | ||
| Clinical response to NAC | Responder | 23 (33.8) | 15 (22.0) | .960 |
| Non responder | 18 (26.5) | 12 (17.7) | ||
| Pathological response to NAC | Responder | 10 (14.7) | 6 (8.8) | .840 |
| Non responder | 31 (45.6) | 21 (30.9) | ||
Upper (Ut), middle (Mt), and lower (Lt) third of thorax.
Well, moderately (Mod), and poorly (Por) differentiated squamous cell carcinoma.
Pathological classification in UICC (7th edition).