Table 4.

Univariate and multivariate analyses of factors associated with overall survival in patients with esophageal squamous cell carcinoma treated with neoadjuvant chemotherapy

	Univariate analysis			Multivariate analysis
	HR	95% CI	P value	HR	95% CI	P value
Age, years
>65	0.98	0.50‐1.84	0.95	0.71	0.35‐1.37	0.31
Sex
Male	1.29	0.51‐4.31	0.62
Tumor location[Link]
Ut	0.76	0.18‐2.11	0.64
Tumor differentiation[Link]
Por	3.74	1.93‐7.12	0.0002	3.04	1.54‐5.92	0.0016
Tumor depth[Link]
pT3‐4	1.53	0.75‐3.41	0.24
Lymph node metastasis[Link]
pN2‐3	6.06	3.08‐12.38	<0.0001
Non‐regional lymph node metastasis[Link]
pM1	3.93	2.02‐7.61	<0.0001
Tumor stage[Link]
III‐IV	4.03	1.80‐10.71	0.0003	3.77	1.63‐10.24	0.0013
MFG‐E8 expression
High	2.46	1.30‐4.65	0.0054	2.07	1.08‐3.99	0.028

Upper (Ut), middle (Mt), and lower (Lt) third of thorax.

Well, moderately (Mod), and poorly (Por) differentiated squamous cell carcinoma.

Pathological classification in UICC (7th edition).

CI, confidence interval; HR, hazard ratio; MFG‐E8, milk fat globule‐epidermal growth factor factor 8.