Table 6.

Short duration supplemented vitamin A diet decreased endocortical circumference and hypervitaminosis A diet decreased cortical bone parameters.

	Control	Supplemented	Hypervitaminosis A
Final body weight (g)	18.6 ± 0.3	18.1 ± 0.2	17.3 ± 0.2**
Liver weight (%)	4.9 ± 0.1	4.9 ± 0.09	5.3 ± 0.1**
Femoral length (mm)	14.2 ± 0.07	14.2 ± 0.05	14.3 ± 0.07
Tb. BMD (mg/cm3)	387.8 ± 9.83	347.3 ± 17.3	360.0 ± 15.5
Endocortical circumference (mm)	3.28 ± 0.03	3.16 ± 0.02**	3.07 ± 0.03***
Periosteal circumference (mm)	4.94 ± 0.03	4.81 ± 0.03**	4.51 ± 0.03***
Cortical BMC (mg/mm)	0.86 ± 0.01	0.83 ± 0.01*	0.64 ± 0.02***
Cortical thickness (µm)	264 ± 3	262 ± 2	229 ± 5***

Final body and relative liver weight, femoral length, trabecular bone mineral density (Tb. BMD), endocortical and periosteal circumferences, cortical bone mineral content (BMC), and cortical thickness as assessed by pQCT of the femur after 8 days of supplemented and hypervitaminosis A diet. Values represented as mean ± s.e.m., n = 10/group, 1-way ANOVA followed by Dunnett’s multiple comparison test vs control.

*P < 0.05, **P < 0.01, ***P < 0.001.