Fig. 3.

Progression of FDG, PiB-R1, and ePiB as a function of EYO across mutation carriers. Plots of standardized estimated difference between MC (red) and NC (blue) participants for FDG (top), PiB-R1 (middle), and ePiB (bottom) at different cortical and subcortical levels: precuneus (left panel), inferior parietal (middle panel), and hippocampus (right panel). FDG and ePiB evolved in opposite directions, whereas PiB-R1 and FDG showed both decrease with EYO. Abbreviations: FDG, ¹⁸F-fluorodeoxyglucose; PiB, ¹¹C-Pittsburgh compound B; EPiB, early frames of the PiB scan; NC, noncarrier; MC, mutation carrier; EYO, estimated year to symptom onset.