Table 2.
Demographics of longitudinal data at baseline
| Parameters | NC | MC | P value |
|---|---|---|---|
| N (%) | 15 (50) | 15 (50) | - |
| Age, mean (SD) years | 40.5 (7.5) | 41.7 (9.0) | .819 |
| EYO, mean (SD) years | −3.8 (7.6) | −4.2 (6.2) | .983 |
| Education, mean (SD) | 14.7 (2.0) | 14.9 (2.0) | .831 |
| Male, n (%) | 6 (40) | 10 (66.7) | .272 |
| CDR > 0, n (%) | 0 | 7 (46.7) | 9.60 × 10−03∗ |
| MCBP > .18, n (%) | 1 (6.7) | 12 (80) | 2.29 × 10−04† |
| MCBP value, mean (SD) | 0.09 (0.2) | 0.53 (0.2) | 8.98 × 10−05† |
Abbreviations: SD, standard deviation; NC, noncarrier; MC, mutation carrier; EYO, estimated year to symptom onset; CDR, clinical dementia rating; MCBP, mean cortical binding potential.
NOTE. In the longitudinal cohort, the 2 groups, NCs and MCs, were similar in age, EYOs, education score, and gender. The MC group had a significant higher proportion of subjects with cognitive impairments (CDR > 0) and amyloid deposition (MCBP > .18).
∗
P value < .01.
†
P value < .001.