Figure 2.

A diagram depicting reverse nucleolar stress in comparison with canonical nucleolar stress. In reverse nucleolar stress, LV induces a reposition of NPM from a scattered nucleolar distribution to a perinucleolar distribution and an increase in nucleolar Nolc1. In canonical nucleolar stress, DXR causes nucleoplasmic translocation of NPM and abolishment of nucleolar Nolc1. Both types of nucleolar stress may lead to eventual cell death. In reverse nucleolar stress, the possibility exists that the cell becomes less malignant, leading to normalization of the cellular structure and function.