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Proposed model. (A) APOBEC3B is activated in an ATR-dependent manner following γ-irradiation. The cells then undergo BER to eliminate uracil from the DNA, and some cells undergoing DNA replication can form DSBs. (B–C) Alternatively, massive deamination reactions are induced in very limited regions and cause further DSBs during the subsequent BER process (B). This event could lead to futile chain reactions of DSB formation and repair (C).
