Table 2.
Summary of anthelmintic activities and selectivity indices of 700015.
| Biological material and parameters assessed | EC50 (parasites) and CC50 (cells) values | Selectivity Indexb | ||
|---|---|---|---|---|
| F. hepatica | Newly excysted juvenilles | Motility | 2.4 μM | 13.3 |
| Phenotype | 2.4 μM | 13.3 | ||
| Immature | Motility | 0.7 μMa | 45.7 | |
| Adult | Motility | 15.6 μM | 2 | |
| S. mansoni | Schistosomula | Motility | 1.9 μM | 16.6 |
| Phenotype | 2.6 μM | 12.2 | ||
| Immature | Motility | 3.4 μM | 9.4 | |
| Adult Male | Motility | 7.4 μM | 4.3 | |
| Adult Female | Motility | 10.3 μM | 3.1 | |
| Cell Lines | MDBK | Viability | 33 μM | |
| HepG2 | Viability | 32 μM | ||
a
The EC50 of 700015 on F. hepatica juveniles is an estimate only.
b
Selectivity indices for F. hepatica lifecycle stages were calculated from MDBK CC50 values; selectivity indices for S. mansoni lifecycle stages were calculated from HepG2 CC50 values.