Fig. 5.
Impact of transientvssustained increase in the [Ca2+]mon mitochondrial dysfunction. Cells were treated as indicated in the legend to Fig. 4, in which a definition of Treatment A-C is also provided. RP-cells received Treatment C also in the presence of 2-APB, Ry or Ru360. After treatments, the cells were analyzed for MitoTracker red CMXRos-fluorescence (A) and cytochrome c localization (B), as detailed in the Methods section. Results represent the means ± SD calculated from 4 to 6 separate experiments. *P < 0.05, **P < 0.01, as compared to untreated cells. (**)P < 0.01, as compared to cells treated with arsenite (one-way ANOVA followed by Dunnet's test).