Table 1.
Cardiac Cine-MRI Assessment of 14-, 21-, and 28-Week-Old BL10/WT, BL10/mdx, D2/WT, and D2/mdx Mice
| 14 Weeks | 21 Weeks | 28 Weeks | |||
|---|---|---|---|---|---|
| Left Ventricle | |||||
| End diastolic volume | BL10 | WT | 68.51 ± 11.62 | 63.84 ± 5.54 | 60.31 ± 4.43 |
| mdx | 66.25 ± 2.98 | 78.71 ± 5.77 | 77.41 ± 9.74 | ||
| D2 | WT | 49.24 ± 4.49 | 46.24 ± 5.94 | 50.25 ± 3.71 | |
| mdx | 47.44 ± 2.43 | 57.66 ± 1.96 | 54.03 ± 4.38 | ||
| End systolic volume | BL10 | WT | 34.32 ± 10.74 | 22.95 ± 3.43 | 21.70 ± 2.99 |
| mdx | 22.62 ± 2.03 | 26.85 ± 3.75 | 28.32 ± 5.92 | ||
| D2 | WT | 12.61 ± 2.11 | 18.13 ± 2.40 | 22.46 ± 3.86 | |
| mdx | 14.34 ± 2.71 | 14.89 ± 3.14 | 18.76 ± 2.83 | ||
| Stroke volume | BL10 | WT | 34.28 ± 2.80 | 40.89 ± 4.01 | 38.61 ± 2.97 |
| mdx | 43.63 ± 1.82* | 51.86 ± 2.97 | 49.09 ± 6.01 | ||
| D2 | WT | 36.63 ± 3.22 | 28.11 ± 3.89 | 27.78 ± 3.62 | |
| mdx | 34.08 ± 1.68 | 42.77 ± 2.51* | 35.28 ± 4.93 | ||
| Ejection fraction | BL10 | WT | 53.76 ± 6.03 | 64.32 ± 4.22 | 64.34 ± 3.40 |
| mdx | 66.06 ± 2.14 | 66.34 ± 2.44 | 65.65 ± 6.04 | ||
| D2 | WT | 74.77 ± 3.11 | 61.14 ± 2.53 | 55.36 ± 5.95 | |
| mdx | 64.18 ± 7.13 | 74.19 ± 4.95* | 64.25 ± 6.04 | ||
| Mass |
BL10 | WT | 112.13 ± 17.98 | 116.58 ± 13.22 | 129.41 ± 5.81 |
| mdx | 109.56 ± 8.00 | 124.49 ± 10.17 | 132.59 ± 14.39 | ||
| D2 |
WT | 106.71 ± 5.82 | 100.27 ± 10.98 | 107.12 ± 12.02 | |
| mdx | 103.05 ± 12.64 | 131.60 ± 7.65* | 135.05 ± 6.80 | ||
| Right Ventricle | |||||
| End diastolic volume | BL10 | WT | 51.77 ± 4.39 | 50.31 ± 9.23 | 53.65 ± 4.89 |
| mdx | 63.05 ± 2.26* | 66.20 ± 7.32 | 74.17 ± 9.75 | ||
| D2 | WT | 63.41 ± 8.09 | 40.40 ± 8.43 | 39.75 ± 5.13 | |
| mdx | 52.13 ± 6.23 | 43.90 ± 6.82 | 40.12 ± 6.26 | ||
| End systolic volume | BL10 | WT | 22.81 ± 5.66 | 18.28 ± 3.53 | 17.15 ± 1.66 |
| mdx | 21.24 ± 1.84 | 23.64 ± 4.25 | 27.41 ± 3.62* | ||
| D2 | WT | 14.98 ± 1.66 | 16.63 ± 3.97 | 18.76 ± 4.40 | |
| mdx | 20.19 ± 5.82 | 13.51 ± 3.27 | 16.62 ± 3.47 | ||
| Stroke volume | BL10 | WT | 28.96 ± 1.40 | 32.03 ± 5.89 | 36.51 ± 4.97 |
| mdx | 41.81 ± 1.24* | 42.56 ± 5.41 | 46.76 ± 7.23 | ||
| D2 | WT | 48.43 ± 7.23 | 23.77 ± 4.88 | 20.99 ± 3.90 | |
| mdx | 31.94 ± 2.87 | 30.39 ± 4.65 | 23.49 ± 4.17 | ||
| Ejection fraction | BL10 | WT | 57.97 ± 6.13 | 64.32 ± 2.64 | 66.97 ± 4.01 |
| mdx | 66.55 ± 2.04 | 64.06 ± 4.80 | 62.40 ± 3.08 | ||
| D2 | WT | 75.50 ± 2.71 | 58.55 ± 3.23 | 52.89 ± 7.77 | |
| mdx | 63.49 ± 5.48 | 69.52 ± 3.65* | 58.76 ± 5.42 | ||
All parameters are expressed as μL with the exception of ejection fraction (%) and mass (mg). Data represented as mean ± SEM, *p < 0.05 versus age-matched WT control, n = 6/group.