Table 1.
Lymphocyte Receptors Targeted by LVs
| IL7R | CD30 | CD19 | CD20 | CD3 | CD4 | CD8 | ||
|---|---|---|---|---|---|---|---|---|
| Expressed on | B cells | yes | yesa | yes | yesb | – | – | – |
| T cells | yes | yesa | – | – | yes | yes | yes | |
| others | – | – | – | – | – | yesd | yese | |
| Targeted by display of | MLV/VSV-LV | IL-7c | – | – | scFv | – | – | |
| SINV-LV | – | – | – | mAB | mAB | – | – | |
| MV-LV | – | scFv | scFv | scFvc | – | DARPinc | scFv | |
| TPMV-LV | – | – | – | scFvc | – | – | – | |
| NiV-LV | – | – | – | scFv | – | – | scFv |
a
Expressed on activated lymphocytes only.
b
Not expressed on early pro-B cells and plasma cells.
c
Transduction of resting and/or minimally activated cells.
d
Monocyte-derived cells.
e
Dendritic cells and NK cell subsets.