Table 1.
Table showing lung function testing and parameters for both patients at time points before and after pneumonia. Note, case 2 completed a 6MWD with no breaks, achieving a distance of 490. Thus, no further 6MWD was completed owing to his improved lung function since his last test.
| Pre-Pneumonia | Post-Pneumonia | Absolute change (Post-Pre) | % change from baseline | |
|---|---|---|---|---|
|
CASE 1 | ||||
| FEV1 (L) (% pred) | 0.97 (27) | 1.18 (33.7) | 0.21 (6.7) | 21.65 (24.81) |
| FVC (L) | 3.83 | 3.27 | −0.56 | −14.62 |
| VC max (L) | 4.23 | 4.79 | 0.56 | 13.24 |
| FEV % VC max | 22.93 | 30.94 | 8.01 | 34.93 |
| TLC (L) | 10.89 | 10.69 | −0.2 | −1.84 |
| RV (L) | 6.82 | 5.89 | −0.93 | −13.64 |
| RV/TLC (%) | 62.65 | 55.13 | −7.52 | −12.00 |
| VC (L) | 4.07 | 4.79 | 0.72 | 17.69 |
| TLCO [mmol/(min*kPa)] | 3.37 | 4.78 | 1.41 | 41.84 |
| KCO [mmol/(min*kPa*L)] | 0.54 | 0.54 | 0 | 0.00 |
| VA (L) | 6.27 | 8.78 | 2.51 | 40.03 |
| 6MWD (m) | 120 | 220 | 100 | 83.33 |
| BODE | 9 | 8 | −1 | −11.11 |
| MMRC dyspnoea scale score | 4 | 4 | 0 | 0.00 |
| CAT score | 32 | 29 | −3 | −9.38 |
| SGRQ | ||||
| health | good | poor | ||
| symptoms | 97.05 | 89.05 | −8 | 8.92 |
| activity | 100 | 100 | 0 | 0.00 |
| impact | 84.86 | 89.41 | 4.55 | 5.36 |
| total | 91.66 | 92.6 | 0.94 | 1.03 |
| BMI |
26.73 |
22 |
−4.73 |
−17.70 |
|
CASE 2 | ||||
| FEV1 (L) (% pred) | 2.38 (56.6) | 4.51 (111) | 2.13 (54.4) | 89.50 (96.11) |
| FVC (L) | 4.9 | 6.2 | 1.3 | 26.53 |
| VC max (L) | 4.9 | 6.3 | 1.4 | 28.57 |
| FEV % VC max | 48.59 | 71.62 | 23.03 | 47.40 |
| TLC (L) | 8.31 | 7.77 | −0.54 | −6.50 |
| RV (L) | 3.68 | 1.76 | −1.92 | −52.17 |
| RV/TLC (%) | 44.23 | 22.59 | −21.64 | −48.93 |
| VC (L) | 4.64 | 6.01 | 1.37 | 29.53 |
| TLCO [mmol/(min*kPa)] | 10.11 | 10.65 | 0.54 | 5.34 |
| KCO [mmol/(min*kPa*L)] | 1.82 | 1.54 | −0.28 | −15.38 |
| VA | 5.56 | 6.93 | 1.37 | 24.64 |
Jones et al (2014) defined minimal clinically important differences (MCIDs) in COPD as: FEV1 change of 100 ml, health status change by 4 units in the St George's Respiratory Questionnaire (SGRQ) (health improvement giving a reduction in score) and change in exercise capacity as 26 ± 2m in 6 minute walking distance [4].