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Effect of tamoxifen on the turnover of Leishmania IPC synthase. IC50 of tamoxifen (2-fold serial dilution from 200 μM top concentration) against the L. major IPC synthase in the in vitro assay was calculated using GraphPad Prism 7 (log (inhibitor) vs. normalized response - Variable slope) as 8.48 μM (95% CI 7.68–9.37). Seven replicate data set, error bars represent standard deviation (not visible where very small), and R2 = 0.98.
