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. 2018 Oct 29;9:644. doi: 10.3389/fendo.2018.00644

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Copyright © 2018 Yang, Luo, Yu, Zhang, Lin, Li, Wu, Su, Zhang, Xiang and Huang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Inhibition of ADH1 level repress Leydig cell differentiation in vivo. (A) Schematic presentation of the experimental design. (B,C) The expression of the NR5A1 and CYP11A1 in Leydig cells at 7 days after EDS treatment. (D,E) The expression of enzymes ADH1 and ALDH1A2, which are involved in RA synthesis, at 7 days after EDS treatment. (F,G) The effects of 4-MP on the expression of the enzymes ADH1 and ALDH1A2 at 35 days after EDS treatment. (H,I) The effects of 4-MP on the expression of the NR5A1 and CYP11A1 at 35 days after EDS treatment. Relative protein expression levels were normalized to GAPDH. Data are expressed as the mean ± SD of n = 8, ^*P < 0.05.