Figure EV5. NFIA ChIP‐seq in GPCs.

• A
  DNA motifs enriched in three groups of CRMs: SOX3/SOX9‐bound CRMs associated with astrocyte genes, SOX9/SOX10‐bound CRMs associated with astrocyte genes, and SOX9/SOX10 CRMs associated with oligodendrocyte genes. Figure shows the two to four most frequent motifs enriched for each group over the other two groups (the most frequent motifs from each group are shown in Fig 4E). Analysis was performed with HOMER software with default settings except for background settings (see Materials and Methods section).
• B
  Histogram showing the correlation between NFIA ChIP experiments (two replicates) and SOX3 ChIP in NPC and GPC and SOX9 ChIP in GPC.
• C
  Centrally enriched NFIA motifs were found in the NFIA consensus peak set.
• D
  NFIA ChIP peaks overlap with 28% of Sox9‐ChIP peaks and with 8% only of the Sox3‐ChIP peaks in GPCs.