Figure 2.

Significant group differences between patients on carbamazepine (CBZ), levetiracetam (LEV), and lamotrigine (LTG) and healthy controls (CTR) are demonstrated on a surface‐rendered brain template, and the subcortical changes are demonstrated on a coronal brain template with a bar chart indicating z score. A, Patients on CBZ activated less in the left inferior frontal gyrus than patients on LEV. In patients on LTG, deactivation was reduced in the task‐negative areas, including the middle frontal gyri and left dorsal parietal region of the precuneus, compared with patients on LEV and CBZ. P < .005, 10‐voxel threshold. B, All 3 groups of patients activated the putamen less bilaterally (left > right) than CTR. Patients on CBZ activated the left inferior frontal gyrus less than CTR. There was less deactivation in the bilateral medial frontal gyri and bilateral lateral temporal regions, left rolandic operculum, and left inferior parietal lobule in patients on LTG. P < .005, 10‐voxel threshold. C, The clinical neuropsychological performance on letter fluency (143) and category fluency (145) in 4 groups together positively correlates with activation in the left putamen. P < .005, 20‐voxel threshold. L, left; R, right