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. 2018 Sep 9;8(18):4884–4897. doi: 10.7150/thno.27581

Figure 6.

Figure 6

(A) Tumor volume and (B) body weight changes of MDA-MB-231 orthotopic breast cancer xenograft mice after 4-dose i.v. injection of different PTX formulations at a normalized PTX dose of 5 mg/kg on day 0, 4, 8 and 12. Saline group served as control. Data are presented as mean ± SD (n=8). *P<0.05; **P<0.01. (C) Representative histological images of MDA-MB-231 tumor xenografts of treated groups using TUNEL assay. Green, apoptotic cells; scale bars represent 50 μm. (D) H&E staining of main organs from MDA-MB-231 tumor xenografts of treated groups; scale bars represent 100 μm.