Figure 14.

A highly efficient, photostable PS and NIR-emissive AIEgen for image-guided photodynamic anticancer therapy. (A) Confocal images of 4T1-luc cancer cells after incubation with TPETCAQ NPs. Cell viability of different PS-treated 4T1-luc cancer cells (B) under light irradiation (60 mW/cm², 5 min) or (C) in the dark. (D) Fluorescence imaging of 4T1-luc tumor-bearing mice after intratumoral administration of TPETACQ NPs (top) or saline (bottom) at 1 h postinjection. (E) Quantitative analysis of bioluminescence signals of 4T1-luc tumor in different mice groups. (F) Tumor volume measurement for different groups of mice. Reproduced with permission from ⁴⁸, copyright 2017 Wiley-VCH.