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(Top) Schematic illustration of the prodrug PyTPE-Pt-D5-cRGD design strategy and the fluorescence turn-on monitoring of drug activation. Confocal images of MDA-MB-231 cells after incubation with PyTPE-Pt-D5-cRGD for 1 h (A), 2 h (B), 4 h (C), and 6 h (D). (E) Cell viability of MDA-MB-231 cells upon treatment with PyTPE-Pt-D5-cRGD at different concentrations. Reproduced with permission from 99, copyright 2014 Royal Society of Chemistry.
