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Estimated absorbed doses for optimized anti-HER2-DOTA-PRIT with 177Lu-DOTA-Bn in nude mice carrying s.c. HER2(+) BT-474 tumors, based on serial biodistribution data from 1.0-336 h p.i. of 177Lu-DOTA-Bn (30 pmol).
| Tissue |
177Lu-DOTA-Bn (cGy/MBq) |
177Lu-therapy Therapeutic Index |
|---|---|---|
| Blood | 1.4 | 28 |
| Tumor | 39.9 | |
| Heart | 0.4 | 100 |
| Lung | 1.3 | 31 |
| Liver | 3.3 | 12 |
| Spleen | 0.3 | 133 |
| Stomach | 0.3 | 133 |
| Small Intestine | 0.4 | 100 |
| Large Intestine | 0.8 | 50 |
| Kidneys | 5.6 | 7 |
| Muscle | 0.9 | 44 |
| Bone | 0.7 | 57 |
