Table 4.
A comparison of hematological parameters between healthy controls, HbSS, and HbSC male patients with sickle cell disease in steady state and in VOC
| Parameters | Control (n=93) (mean±SD) | HbSS steady state (n=110) (mean±SD) | HbSC steady state (n=30) (mean±SD) | HbSS VOC (n=64) (mean±SD) | HbSC VOC (n=12) (mean±SD) | P-value |
|---|---|---|---|---|---|---|
|
| ||||||
| Hb (g/dL) | 15.38±3.68 | 8.53±1.61 | 12.51±1.33 | 9.24±1.67 | 12.10±1.63 | <0.001* |
| HCT (%) | 42.20±6.51 | 25.82±5.15 | 39.83±4.63 | 28.37±6.01 | 38.35±4.37 | <0.001* |
| RBC (106/mm3) | 5.14±0.82 | 3.06±0.71 | 4.82±0.49 | 3.50±0.89 | 4.45±0.53 | <0.001* |
| MCV (µm3) | 82.62±6.09 | 84.97±8.47 | 82.90±5.15 | 82.59±9.45 | 84.42±6.20 | 0.185 |
| MCH (pg) | 27.44±2.67 | 28.20±3.51 | 26.02±1.83 | 27.50±6.95 | 27.20±2.04 | 0.274 |
| MCHC (g/dL) | 33.18±1.36 | 33.12±1.46 | 30.02±1.83 | 33.03±4.92 | 32.24±0.58 | <0.001* |
| RDW (%) | 18.91±13.25 | 18.56±2.54 | 14.97±1.35 | 18.56±2.89 | 15.43±1.16 | <0.001* |
| MPV (µm3) | 9.09±1.38 | 7.47±0.69 | 8.32±1.01 | 7.65±0.81 | 7.88±0.77 | <0.001* |
| PDW (%) | 13.76±1.92 | 13.92±2.26 | 14.23±2.23 | 13.19±3.01 | 13.42±2.22 | 0.0900 |
| PLT (103/mm3) | 224.22±61.17 | 466.33±121.39 | 289.64±18.31 | 439.34±158.77 | 238.56±109.94 | <0.001* |
| PCT (%) | 0.18±0.07 | 0.35±0.10 | 0.23±0.08 | 0.34±0.12 | 0.19±0.07 | <0.001* |
| WBC (103/mm3) | 5.31±1.11 | 12.18±3.56 | 6.87±1.77 | 16.24±7.37 | 9.78±2.09 | <0.001* |
Note:
*
Significant.
Abbreviations: HCT, hematocrit; Hb, hemoglobin; MCH, mean cell hemoglobin; MCHC, mean cell hemoglobin concentration; MCV, mean cell volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; PLT, platelets; RBC, red blood cell; RDW, red cell distribution width; VOC, vaso-occlusive crises; WBC, white blood cells.