Table 2.
Distributions of the three SNPs and alleles in two groups and their relationship with susceptibility of lung cancer
| SNP | Lung cancer
|
|||
|---|---|---|---|---|
| Cases, n (%) | Controls, n (%) | ORa (95% CI) | Pb | |
|
| ||||
| rs920778 | ||||
| TT | 324 (59.7) | 326 (59.2) | 1 (ref) | |
| TC | 197 (36.3) | 203 (36.8) | 1.026 (0.800–1.317) | 0.838 |
| CC | 22 (4.1) | 22 (4.0) | 0.989 (0.537–1.823) | 0.973 |
| TC+CC vs TT | 1.023 (0.803–1.302) | 0.856 | ||
| CC vs TT+TC | 0.980 (0.536–1.792) | 0.947 | ||
| T allele | 845 (77.8) | 855 (77.6) | ||
| C allele | 241 (22.2) | 247 (22.4) | 1.013 (0.828–1.239) | 0.901 |
| rs12826786 | ||||
| CC | 340 (62.6) | 381 (69.1) | 1 (ref) | |
| CT | 185 (34.1) | 156 (28.3) | 0.757 (0.584–0.980) | 0.035* |
| TT | 18 (3.3) | 14 (2.5) | 0.696 (0.341–1.422) | 0.321 |
| CT+TT vs CC | 0.751 (0.584–0.966) | 0.026* | ||
| TT vs CC+CT | 0.762 (0.375–1.548) | 0.452 | ||
| C allele | 865 (79.7) | 918 (83.3) | ||
| T allele | 221 (20.3) | 184 (16.7) | 0.785 (0.632–0.974) | 0.028* |
| rs4759314 | ||||
| AA | 526 (96.9) | 489 (88.7) | 1.00 (ref) | |
| AG | 16 (2.9) | 61 (11.1) | 4.048 (2.302–7.120) | <0.001* |
| GG | 1 (0.2) | 1 (0.2) | 1.023 (0.064–16.440) | 0.987 |
| GG+AG vs AA | 3.869 (2.230–6.714) | <0.001* | ||
| GG vs AA+AG | 0.931 (0.058–14.965) | 0.960 | ||
| A allele | 1,068 (98.3) | 1,039 (94.3) | ||
| G allele | 18 (1.7) | 63 (5.7) | 3.598 (2.116–6.117) | <0.001* |
Notes:
a
OR adjusted for age;
b
P-value adjusted for age
*
Indicates statistical significance (P<0.05).
Abbreviations: ref, reference; SNP, single nucleotide polymorphism.