Table 7.
Distributions of the three SNPs and alleles in two groups and their relationship with susceptibility of squamous lung cancer
| SNP | Squamous lung cancer
|
|||
|---|---|---|---|---|
| Controls, n (%) | Cases, n (%) | ORa (95% CI) | Pb | |
|
| ||||
| rs920778 | ||||
| TT | 324 (59.7) | 76 (58) | 1.00 (ref) | |
| TC | 197 (36.3) | 51 (38.9) | 1.165 (0.785–1.730) | 0.449 |
| CC | 22 (4.1) | 4 (3.1) | 0.751 (0.250–2.250) | 0.609 |
| TC+CC vs TT | 1.122 (0.762–1.650) | 0.560 | ||
| CC vs TT+TC | 0.707 (0.239–2.095) | 0.532 | ||
| T allele | 845 (77.8) | 203 (77.5) | 1.00 (ref) | 0.909 |
| C allele | 241 (22.2) | 59 (22.5) | 1.019 (0.738–1.408) | |
| rs12826786 | ||||
| CC | 340 (62.6) | 91 (69.5) | 1.00 (ref) | |
| CT | 185 (34.1) | 38 (29.0) | 0.786 (0.516–1.198) | 0.262 |
| TT | 18 (3.3) | 2 (1.5) | 0.406 (0.092–1.790) | 0.234 |
| CT+TT vs CC | 0.751 (0.497–1.135) | 0.174 | ||
| TT vs CC+CT | 0.439 (0.100–1.923) | 0.275 | ||
| C allele | 865 (79.7) | 220 (84.0) | 1.00 (ref) | 0.113 |
| T allele | 221 (20.3) | 42 (16.0) | 0.747 (0.520–1.073) | |
| rs4759314 | ||||
| AA | 526 (96.9) | 114 (86.9) | 1.00 (ref) | |
| AG | 16 (2.9) | 17 (13.1) | 4.671 (2.279–9.572) | <0.001* |
| GG | 1 (0.2) | 0 (0.0) | – | – |
| GG+AG vs AA | 4.614 (2.286–9.311) | <0.001* | ||
| GG vs AA+AG | – | – | ||
| A allele | 1,068 (98.3) | 245 (93.5) | 1.00(ref) | <0.001* |
| G allele | 18 (1.7) | 17 (6.5) | 4.117 (2.092–8.104) | |
Notes:
a
OR adjusted for age;
b
P-value adjusted for age;
*
Indicates statistical significance (P<0.05); – indicates the results cannot be calculated.
Abbreviations: ref, reference; SNP, single nucleotide polymorphism.