Table 1.

Microarray analysis of LAM tissue in WT and Arom^hum mice

Gene symbol	Definition	Fold-change	Adjusted P value
Top 13 up-regulated fibrotic genes in LAM of Aromhum mouse
Kiss1	KiSS-1 metastasis-suppressor	31.13	0.009
Ren1	Renin 1 structural	7.87	0.026
Emb	Embigin	5.20	0.020
Krt8	Keratin 8	4.38	0.005
Timp1	Tissue inhibitor of metalloproteinase 1, transcript variant 2	4.19	0.009
Krt7	Keratin 7	3.05	0.007
Spon2	Spondin 2, extracellular matrix protein	2.83	0.058
Krt18	Keratin 18	2.71	0.013
Spon1	Spondin 1, (f-spondin) extracellular matrix protein	2.54	0.009
Tnc	Tenascin C	2.52	0.079
Plod2	Procollagen lysine, 2-oxoglutarate 5-dioxygenase 2	2.42	0.018
Eln	Elastin	2.38	0.020
Col8a1	Collagen, type VIII, α1	2.21	0.040
Top 8 down-regulated androgen responsive genes in LAM of Aromhum mouse
Amd2	S-adenosylmethionine decarboxylase 2	3.43	0.036
Cyp2e1	Cytochrome P450, family 2, subfamily e, polypeptide 1	3.22	0.045
Cpeb4	Cytoplasmic polyadenylation element binding protein 4	1.89	0.025
Idh3g	Isocitrate dehydrogenase 3 (NAD+), γ	1.85	0.015
Tiam1	T cell lymphoma invasion and metastasis 1	1.77	0.037
Cntnap2	Contactin associated protein-like 2	1.75	0.043
Tst	Thiosulfate sulfurtransferase, mitochondrial	1.75	0.037
Hrasls	HRAS-like suppressor	1.73	0.043

Fibrotic genes were up-regulated and androgen-responsive genes were down-regulated in Arom^hum mice vs. WT mice.