Fig. 5.

Alternative pathways for lysine biosynthesis. (A) Sketches of six alternative lysine biosynthetic pathways (with KEGG identifiers), along with their cofactor usage. (B) Thermodynamics of alternative pathways as a function of temperature. The pathway ${\mathrm{\Delta }}_{r}G\text{'}°$ values relative to that of the pathway with the highest ${\mathrm{\Delta }}_{r}G\text{'}°$ at 298.15 K, pH 7, and ionic strength 0.25 M (reference ${\mathrm{\Delta }}_{r}G\text{'}°$). (C) Maximum culture temperature of organisms containing pathways M00031, M00526, and M00016. (D) Alternative lysine biosynthetic pathways in Chloroflexi phylum. Glu/α-KG, glutamate/α-ketoglutarate.