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Interaction of tRNAs with the ribosome. (A) tRNA tertiary structure with nucleotides in which mutations cause mRNA frameshifts, highlighted in orange. (B) tRNA interactions with the A, P, and E sites on the ribosome (PDB ID code 4V51). (Insets) The extensive interactions of the 16S rRNA with the mRNA-tRNA pair at the A site, which are absent in the P and the E sites.
