Table 3. Multivariable models of factors associated with any wheeze and persistent wheeze including effects of adiposity.

	Any Wheeze
	Android			Gynoid			Trunk			Total Body
Characteristic	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value
Hay fever (ref: never)	2.07	1.19, 3.61	0.01	2.01	1.16, 3.51	0.01	2.05	1.18, 3.56	0.01	1.96	1.13, 3.41	0.02
Cigarette Smoking
Current ≥1/2 pack/day	7.88	3.08, 20.14	<0.01	7.38	2.88, 18.91	<0.01	7.86	3.05, 20.23	<0.01	7.51	2.92, 19.30	<0.01
Current <1/2 pack/day	2.34	1.01, 5.40	0.05	2.38	1.04, 5.44	0.04	2.33	1.01, 5.33	0.04	2.32	1.01, 5.32	0.05
Former	2.39	1.42, 4.00	<0.01	2.24	1.36, 3.69	<0.01	2.08	1.26, 3.43	0.01	2.05	1.24, 3.38	<0.01
Never	ref			ref			ref			ref
Region %fat*
quartile 1 (lowest)	ref			ref			ref			ref
quartile 2	1.22	0.63, 2.37	0.55	1.94	0.99, 3.80	0.05	1.77	0.92, 3.43	0.09	2.34	1.20, 4.57	0.01
quartile 3	1.25	0.63, 2.47	0.53	2.30	1.19, 4.43	0.01	2.28	1.16, 4.48	0.02	2.49	1.27, 4.89	0.01
quartile 4 (highest)	2.89	1.48, 5.65	<0.01	1.78	0.93, 3.40	0.08	2.62	1.33, 5.16	0.01	2.72	1.38, 5.34	<0.01
Continuous %fat**	1.03	1.01, 1.05	0.01	1.02	1.01 1.05	0.06	1.03	1.01, 1.05	0.01	1.04	1.01, 1.06	<0.01
	Persistent Wheeze
	Android			Gynoid			Trunk			Total Body
Characteristic	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value	Odds Ratio	95% C.I.	p-value
Heart disease last 10yrs (ref: never)	3.55	1.64, 7.68	<0.01	3.41	1.57, 7.44	<0.01	3.37	1.56, 7.26	<0.01	3.22	1.49, 6.94	<0.01
Cigarette Smoking
Current ≥1/2 pack/day	6.99	2.63, 18.56	<0.01	6.58	2.52, 17.17	<0.01	6.68	2.52, 17.67	<0.01	6.51	2.46, 17.18	<0.01
Current <1/2 pack/day	3.15	1.16, 8.56	0.02	3.02	1.11, 8.19	0.03	3.23	1.20, 8.75	0.02	3.09	1.14, 8.36	0.03
Former	1.57	0.78, 3.15	0.21	1.52	0.76, 3.04	0.23	1.39	0.70, 2.76	0.35	1.40	0.71, 2.78	0.33
Never	ref			ref			ref			ref
Region %fat*
quartile 1 (lowest)	ref			ref			ref			ref
quartile 2	0.78	0.33, 1.83	0.57	1.39	0.57, 3.37	0.47	1.15	0.48, 2.74	0.76	1.57	0.65, 3.83	0.32
quartile 3	1.26	0.52, 3.04	0.61	3.21	1.41, 7.29	0.01	2.70	1.15, 6.31	0.02	3.24	1.37, 7.67	<0.01
quartile 4 (highest)	2.16	0.95, 4.90	0.07	1.38	0.57, 3.35	0.48	1.95	0.81, 4.72	0.14	2.06	0.83, 5.09	0.12
Continuous %fat***	1.02	1.00, 1.05	0.10	1.02	0.99, 1.05	0.31	1.03	1.00, 1.05	0.09	1.03	0.99, 1.06	0.11

*Android, % fat quartiles: - ≤ 36,> 36- ≤ 45, >45- ≤ 52, >52%

Gynoid, % fat quartiles: ≤ 34, >34-≤ 40, >40-≤ 47, >47%

Trunk, % fat quartiles: ≤ 34,> 34-≤ 42, >42-≤ 48, >48%

Total body, % fat quartiles: ≤ 31, >31-≤ 38, >38-≤ 43, >43%

**Adjusted for hay fever and cigarette smoking

***Adjusted for heart disease in the last 10 yrs and cigarette smoking