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. 2018 Oct 1;3(10):12330–12340. doi: 10.1021/acsomega.8b01465

Figure 3.

Figure 3

RMSD plots of disulfide bond opened versions of the five μ-conotoxins. The comparison of backbone stability between the peptides with the C2–C5 disulfide bond removed (black) and both the C2–C5 and C3–C6 bridges removed (red) between 100 and 300 ns of simulation time: (A) μ-GIIIA, (B) μ-KIIIA, (C) μ-PIIIA, (D) μ-SIIIA, and (E) μ-SmIIIA. Above the plots is a representation of two cases of disulfide connectivity discussed. Here, red represents the version with the single C1–C4 disulfide bond and black represents the C1–C4/C3–C6 disulfide connectivity.