Scheme 2. Self-Assembly of (i) Linear, (ii) V-, and (iii) Y-Shape Multi-FITC-Labeled siRNA Constructs^,

The green label represents fluorescent (FL) FITC-labeled sequences for linear (L), V-shape (V), and Y-shape (Y) siRNAs containing a single (1F), double (2F), and triple (3F) fluorophores.

Antisense (A) and sense (S) strands were hybridized to target a first (1) or second (2) mRNA site belonging to GRP 75, 78, and 94.