Figure 1.

Study design. The study comprised of gene expression data acquired from male Sprague-Dawley rats dosed once daily in triplicate for 3, 5, or 7 days depending on the test chemical or matched control, and livers were harvested 24 h after the last dose. The abbreviations for the names of the chemicals are listed in Table 1. There were five modes of action (MOAs) with three chemicals per MOA. The MOAs are PPARA, peroxisome proliferator-activated receptor alpha; CAR/PXR, orphan nuclear hormone receptors; AhR, aryl hydrocarbon receptor; Cytotoxic, cytotoxicity, and DNA Damage. Comparisons between the data from TempO-Seq to microarray and RNA-Seq were performed by statistical and bioinformatics methodologies.