Table 1.
Chemicals, modes of action, and exposures.
| MOA | Chemical | Dose (mg/kg body weight) | Duration (days) | Agent type |
|---|---|---|---|---|
| Aryl hydrocarbon receptor (AhR) | 3-Methylcholanthrene (3ME) | 300 | 5 | Carcinogen |
| Leflunomide (LEF) | 60 | 5 | Antirheumatic drug | |
| beta-Naphthoflavone (NAP) | 1,500 | 5 | Putative chemopreventive agent | |
| Orphan nuclear hormone receptors (CAR/PXR) | Phenobarbital (PHE) | 54 | 5 | Barbiturate drug |
| Methimazole (MET) | 100 | 3 | Antithyroid drug | |
| Econazole (ECO) | 334 | 5 | Antifungal medication | |
| Cytotoxicity (Cytotox) | Chloroform (CHO) | 600 | 5 | Organic compound |
| Thioacetamide (THI) | 200 | 5 | Carcinogen | |
| Carbon tetrachloride (CAR) | 1,175 | 7 | Solvent for cleaning products, refrigerant | |
| DNA Damage (DNA_Damage) | Aflatoxin B1 (AFL) | 0.3 | 5 | Mycotoxin |
| Ifosfamide (IFO) | 143 | 3 | Chemotherapy drug | |
| N-Nitrosodimethylamine (NIT) | 10 | 5 | Organic compound | |
| Peroxisome proliferator-activated receptor alpha (PPARA) | Pirinixic acid (PIR) | 364 | 5 | Hypolipidemic drug |
| Bezafibrate (BEZ) | 617 | 7 | Hypolipidemic drug | |
| Nafenopin (NAF) | 338 | 5 | Hypolipidemic drug |