Table 3. Ex Vivo Biodistribution in Normal Mice (ICR, 18–22 g, Male) after Intravenous Injection of [18F]17a.
| organ | 2 min | 10 min | 30 min | 60 min |
|---|---|---|---|---|
| blood | 7.81 ± 0.85 | 3.58 ± 1.31 | 0.54 ± 0.12 | 0.31 ± 0.06 |
| brain | 0.30 ± 0.04 | 0.16 ± 0.05 | 0.12 ± 0.10 | 0.09 ± 0.05 |
| heart | 8.65 ± 1.34 | 4.12 ± 1.46 | 0.83 ± 0.14 | 0.62 ± 0.26 |
| liver | 37.71 ± 3.47 | 74.71 ± 5.23 | 77.17 ± 7.73 | 57.18 ± 3.70 |
| spleen | 8.38 ± 1.84 | 6.94 ± 1.83 | 1.76 ± 0.14 | 1.01 ± 0.40 |
| lung | 15.59 ± 3.18 | 9.21 ± 2.33 | 1.83 ± 0.48 | 1.12 ± 0.26 |
| kidney | 14.06 ± 1.82 | 8.06 ± 2.28 | 3.46 ± 0.47 | 3.83 ± 0.89 |
| pancreas | 4.96 ± 0.38 | 3.16 ± 0.66 | 1.20 ± 0.20 | 1.14 ± 0.70 |
| muscle | 3.28 ± 0.47 | 2.96 ± 0.69 | 0.80 ± 0.09 | 0.81 ± 0.76 |
| bone | 3.14 ± 0.57 | 1.97 ± 0.79 | 1.38 ± 0.45 | 1.44 ± 0.53 |
| stomachb | 1.00 ± 0.18 | 1.05 ± 0.26 | 2.81 ± 2.13 | 3.83 ± 1.39 |
| intestineb | 5.60 ± 1.41 | 8.59 ± 2.00 | 14.22 ± 4.03 | 37.64 ± 6.80 |
Expressed as % injected dose per gram. Each value represents the mean ± SD for 5 mice at each interval.
Expressed as % injected dose per organ.