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Electrostatic surface representation of the hIRE1 kinase active site in (A) apo form (PDB code: 5HGI) (B) with the KIRA molecule cocrystallized (PDB code: 4U6R) and (C) with ADP cocrystallized (PDB code: 3P23). Standard coloring scheme was used: red for negative, white for neutral, and blue for positive electrostatic potential.
