Table 1. Crystal Structures Available for IRE1 in Different Organisms.
| PDB code | ligand IDa | resolution (Å) | organism | assembly | # of mutation (s) | references |
|---|---|---|---|---|---|---|
| 3SDJ | APJ (2) | 3.65 | Saccharomyces cerevisiae | oligomer | 29 | (18) |
| 3SDM | (Apo) | 6.6 | S. cerevisiae | oligomer | 28 | (19) |
| 3LJ0 | ADP (1) | 3.2 | S. cerevisiae | dimer | 24 | (20) |
| 3LJ1 | DKI (3) | 3.33 | S. cerevisiae | dimer | 24 | (21) |
| 3LJ2 | IZA (4) | 3.33 | S. cerevisiae | dimer | 24 | (21) |
| 3FBV | APJ (2) | 3.2 | S. cerevisiae | oligomer | 28 | (22) |
| 2RIO | ADP (1) | 2.4 | S. cerevisiae | dimer | wild-type | (7) |
| 2BE1 | (Apo) | 2.98 | S. cerevisiae | dimer | wild-type | (23) |
| 4PL3 | ADP (1) | 2.9 | Mus musculus | dimer | 1 | (12) |
| 4PL4 | ADP (1) | 3.0 | M. musculus | tetramer | 1 | (12) |
| 4PL5 | ADP (1) | 3.4 | M. musculus | tetramer | 1 | (12) |
| 5HGI | (Apo) | 2.58 | Homo sapiens | dimer | wild-type | (13) |
| 4YZ9 | 4K7 (5) | 2.46 | H. sapiens | dimer | wild-type | (24) |
| 4YZC | STU (8) | 2.49 | H. sapiens | monomer | wild-type | (25) |
| 4YZD | ADP (1) | 3.1 | H. sapiens | monomer | wild-type | (25) |
| 4Z7G | (Apo) | 2.6 | H. sapiens | monomer | wild-type | (26) |
| 4Z7H | 4L5 (6) | 2.9 | H. sapiens | monomer | wild-type | (26) |
| 4U6R | 3E4 (7) | 2.5 | H. sapiens | monomer | 1 | (11) |
| 3P23 | ADP (1) | 2.7 | H. sapiens | dimer | 1 | (27) |
| 2HZ6 | (Apo) | 3.1 | H. sapiens | dimer | 2 | (28) |