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. 2018 Oct 19;3(10):13576–13583. doi: 10.1021/acsomega.8b01859

Figure 1.

Figure 1

(a) Illustration of the systematic evolution of ligand by exponential enrichment process. Library molecules that bind to negative targets (undesired targets) are washed away, and those that bind to the positive target (atrazine in this study) are retrieved and amplified by PCR. This completes one round of SELEX. (b) Illustration of the library immobilization process for the modified Capture-SELEX. Biotinylated cDNA probes are first captured on streptavidin coated magnetic beads. Library ssDNA molecules dehybridized by positive target induction are retrieved and subsequently amplified.