Skip to main content
. 2018 Oct 19;3(10):13647–13666. doi: 10.1021/acsomega.8b01481

Scheme 2. Synthesis of N-Boc-3-(Thiazol-4-yl)-l-alanine 3a.

Scheme 2

Reagents and conditions: (a) Lawesson’s reagent, THF, 0 °C; (b) 1,3-dichloroacetone, THF, 0 °C, 63%; (c) diethyl acetamidomalonate, NaOEt, KI, EtOH, reflux, 89%; (d) conc. aq. HCl, reflux, 74%; (e) aq. NaOH, Ac2O; and (f) 1) aminoacylase, 37 °C, pH 7.2; 2) Boc2O, THF, rt, 29%.