Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Reagents and conditions: (a) (1) ClCO2Et, Et3N, THF, −25 °C; (2) aq. NH3, THF, −25 °C, 86%; (b) POCl3, imidazole, pyridine, 0 °C to rt, 90%; (c) (1) TFA, anisole, 0 °C; (2) p-TsOH·H2O, quant; (d) BH3-THF complex, THF, 0 °C, 98%; (e) MsCl, Et3N, THF, 0 °C, 95%; (f) NaBH4, DMSO, 80 °C, 46%; and (g) HCl in 1,4-dioxane, rt, quant.
