Scheme 6. General Synthetic Route of TRH Mimetics Including 4a and 4b as Middle-Part Fragments.
Reagents and conditions: (a) DCC, HOBt or HOSu, DMF, 0 °C to rt; (b) HCl or TFA or p-TsOH·H2O, 0–50 °C; and (c) DCC, HOSu, Et3N, DMF, 0 °C to rt.
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