Table 3. Area under the Rectal Temperature–Time Curve after Oral Administration to Reserpine-Induced Hypothermia Mice of TRH and 79 at a Dose of 50 and 5 μmol/kg, Respectivelya.
| rectal
temperature |
||
|---|---|---|
| compounds (dose) | AUC0–7h (°C·h)b | ΔAUC0–7h (°C·h)c |
| vehicle | 205.4 ± 11.1 | |
| TRH (50 μmol/kg) | 201.4 ± 3.3 | –4.0 ± 3.3 |
| 79 (5 μmol/kg) | 233.4 ± 4.3 | 28.0 ± 4.3 |
a
Each value represents the mean ± SD of at least three animals.
b
AUC0–7h was calculated by using the trapezoidal method.
c
ΔAUC = AUC0–7h(compounds) – AUC0–7h(saline).