Table 4. PK Parameters of TRH and 79 after Oral Administration to Fasted Conscious Rats at a Dose of 40 mg/kg^a.

compounds	Cmax (ng/mL)	Tmax (h)	AUC0–8h (ng·h/mL)b	brain Kpc
TRH	50 ± 39	0.75 ± 0.29	68 ± 72	NDd
79	636 ± 232	0.25 ± 0.00	817 ± 349	0.06 ± 0.03

^aEach value represents the mean ± SD of at least four animals.

^bAUC_0–8h was calculated by using the trapezoidal method.

^c

Brain Kp was calculated by the equation below.

Plasma and brain (ventral tegmental area) free concentration were determined after oral administration to rats at a dose of 40 mg/kg.

^dNo data.