Figure 4.

Gene modules affected by dengue virus vaccination and natural infection. A, Blood transcript modules with transcripts that were significantly up- or down-regulated on at least 1 day (false discovery rate <1%) were hierarchically clustered. Vertical lines on right denote module clusters described in the text. B, Hierarchical clustering of each day postvaccination or postinfection using the normalized enrichment score from (A). Days in bold italics represent days of fever for infected patients; days preceded by “v” represent days postvaccination. Abbreviations: Ag, antigen; IFN, interferon; NES, normalized enrichment score.