Figure 4.

Pericyte Fli-1 knockout (KO) reverses cecal ligation and puncture (CLP)-induced lung and kidney vascular leakage and mortality. Wild-type (WT) and Foxd1 Fli-1 KO mice were subjected to sham or CLP. Lung (A) and (B) kidney vascular leakage (n = 4 mice per group) and mice survival ([C] n = 15 mice per group) were determined. Survival of mice was monitored for 7 days. Mice numbers in each group were labeled as survived/total mice. Data are expressed as means ± standard error. *, P < .05 compared with WT sham group; ^#, P < .05 compared with WT CLP group by analysis of variance with Fisher’s probable least-squares difference test. Survival was analyzed by log-rank (Mantel-Cox) test.