Table 3.

KIR-HLA Combinations Are Associated With Cervical Neoplasia

Combination			OR		Sample Size		HLA Frequency		KIR Frequency		KIR+HLA+		KIR-HLA-		KIR+HLA-		KIR-HLA+
HLA Allele	KIR Gene	P a	Omni- Ichip1	660Q- Ichip2	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls	Cases	Controls
HLA-B*5501	KIR2DS2	5.97 × 10−5	0.61	0.19	2019	12650	0.034	0.034	0.52	0.51	21	240	923	5994	1028	6230	47	186
HLA-B*5501	KIR2DL2	.00013	0.6	0.21	1983	12563	0.034	0.033	0.511	0.508	21	233	922	5993	993	6151	47	186
HLA- DQB1*0601	KIR2DL3	.0032	0.14	0.17	2062	12975	0.012	0.0097	0.905	0.905	17	118	188	1215	1850	11634	7	8
HLA- DRB1*1502	KIR2DL3	.0042	0.2	0.18	1920	12349	0.012	0.0104	0.908	0.908	16	119	170	1133	1727	11088	7	9
HLA-B*3801	KIR2DS4TOTAL	.0047	0.16	0.19	2056	12800	0.025	0.023	0.956	0.955	46	287	85	575	1919	11931	6	7
HLA-B*3801	KIR3DL1ex4	.0047	0.16	0.16	2055	12807	0.025	0.023	0.956	0.954	46	287	85	576	1918	11937	6	7
HLA-B*3801	KIR3DL1ex9	.0048	0.16	0.19	2053	12805	0.026	0.023	0.956	0.954	47	290	85	575	1915	11933	6	7
HLA- DQA1*0103	KIR2DL3	.0078	0.57	0.5	2078	13106	0.084	0.120	0.905	0.906	147	1422	170	1086	1733	10453	28	145

Data are no. of cervical neoplasia cases and healthy controls with the specified KIR-HLA combinations, unless otherwise indicated.

Abbreviations: OR, odds ratio; -, negative; +, positive.

^aCombination P values were calculated from a meta-analysis between Omni-Ichip1 and 660Q-Ichip2 data sets; P values of each data set were calculated by using the R code glm model with principal components 1–4.