Table 1.
Demographics and characteristics of the study cohorts
| Controls | All MS | MSNON | MSON | P value | |||||
|---|---|---|---|---|---|---|---|---|---|
| (40, eyes)a | (38, eyes) | (25, eyes) | (13, eyes) | (All MS vs. HC) | (MSNON vs. HC) | (MSON vs. HC) | (MSON vs. MSNON) | ||
| Age, yr.; mean (SD) | 29.8 (10.3) | 36.4 (10.4) | 36.9 (11.2) | 35.6 (9.1) | 0.002 b | 0.009 b | 0.013 b | 0.7b | |
| Sex; Female n (%) | 14 (70%) | 27 (71%) | 18 (72%) | 9 (69%) | 0.92c | 0.86c | 0.96c | 0.86c | |
| Disease Duration, yr.; median (Q1–3) | – | 7 (3,15) | 6 (3,13) | 8 (4,15) | – | – | – | 0.44b | |
| Race; Caucasian n (%) | 11 (55%) | 23 (65%) | 15 (60%) | 8 (62%) | 0.13c | 0.27c | 0.54c | 1.00c | |
| Contrast Letter Acuity; mean (SD) | 100% | – | 55.9 (11.1) | 57.0 (10.3) | 54.0 (12.7) | – | – | – | 0.63b |
| 2.5% | – | 26.6 (13.7) | 26.6 (13.9) | 26.5 (13.8) | – | – | – | 0.87b | |
| 1.25% | – | 12.2 (11.5) | 13.5 (12.2) | 9.8 (10.2) | – | – | – | 0.34b | |
HCs = healthy controls; MS = multiple sclerosis; MSNON = MS without optic neuritis; MSON = MS with optic neuritis; yr = year; SD = standard deviation; Q1 = first quartile; Q3 = third quartile
aboth eyes of HCs were included in the study (HC subjects, n = 20) while only one eye of each patient with MS was included (MS patients, n = MS eyes)
bWilcoxon rank-sum test
cChi-squared test
P ≤ 0.05 indicates significance