Table 1.
Median cytokine concentrations in participants with morphea and healthy control subjects
| Analyte (pg/ml) | Morphea Patients (n = 72) | Healthy Control Subjects (n = 26) | P-Value | ||
|---|---|---|---|---|---|
| Median | IQR | Median | IQR | ||
| TH1 cytokines | |||||
| IL-2 | 3.0 | 2.2–3.9 | 2.2 | 1.7–2.7 | 0.003 |
| IL-2R | 235.6 | 193.1–272.9 | 171.3 | 163.8–208.5 | <0.00011 |
| IL-12 | 249.0 | 217.1–302.1 | 208.1 | 190.1–236.5 | 0.00051 |
| MIP-1α | 43.61 | 37.8–57.1 | 37.5 | 34.8–42.1 | 0.00011 |
| TNF-α | 2.3 | 1.6–3.0 | 1.9 | 1.5–2.7 | 0.03 |
| CXCL9 | 52.7 | 32.1–99.9 | 27.5 | 23.4–35.4 | <0.00011 |
| CXCL10 | 14.3 | 9.7–22.4 | 8.5 | 6.9–11.6 | <0.00011 |
| IFN-γ | 22.4 | 1 8.4–24.8 | 21.06 | 18.6–23.9 | 0.77 |
| TH2 cytokines | |||||
| IL-4 | 10.3 | 8.8–12.0 | 8.9 | 8.7–10.3 | 0.04 |
| IL-13 | 23.0 | 13.1–33.8 | 16.3 | 5.3–22.8 | 0.008 |
| Other analytes of interest | |||||
| IL1-RA | 244.5 | 141.5–431.9 | 160.4 | 94.2–282.5 | 0.02 |
| IFN-α | 30.9 | 27.9–34.3 | 30.1 | 27.9–30.7 | 0.03 |
| G-CSF | 124.6 | 110.7–141.6 | 106.1 | 90.9–111.1 | 0.003 |
| IL-6 | 4.3 | 2.6–10.3 | 2.8 | 1.9–4.2 | 0.02 |
| IL-8 | 43.2 | 30.9–93.9 | 22.3 | 15.1–35.8 | 0.0004 |
| MCP-1 | 476.4 | 358.2–645.7 | 366.2 | 313.7–428.5 | 0.01 |
| IL-1β | 5.53 | 0.2–11.8 | 0.2 | 0.2–3.3 | 0.003 |
| RANTES | 5,717 | 4,715–7,493 | 8275 | 6086–9761 | 0.001 |
Abbreviations: IQR, interquartile range; TH1, T helper type 1; TH2, T helper type 2.
1
Indicates cytokines significant with Bonferroni correction.