. Author manuscript; available in PMC: 2019 Nov 5.

Published in final edited form as: Eur J Med Chem. 2018 Sep 21;159:217–242. doi: 10.1016/j.ejmech.2018.09.043

Table 1.

Cytotoxicity, CD98 down-regulation and vacuolation profiles of the new C-3-arylalkyl chain variants of analog 3

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Comp.	IC50 (μM) [95% CI]		%CD98 down-regulation			Vacuolation score

			2.5 μM	10 μM	40 μM	2.5 μM	10 μM	40 μM
1	2.1	[1.9, 2.4]	30	63	n.d.	+++	+++	n.d.
3	2.1	[2.0, 2.2]	41	66	n.d.	++	+++	n.d.
4	10.9	[8.7, 13.7]	11	14	51	n.d.	0	0
5	10.2	[8.7, 12.0]	5	18	61	n.d.	0	0
6	8.4	[7.0, 10.1]	5	33	61	n.d.	0	0
7	15.1	[11.2, 20.3]	−15	−8	23	n.d.	0	0