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Cytotoxicity, CD98 down-regulation and vacuolation profiles of phosphate ester analogs
| Comp. | IC50 (μM) [95% CI] | %CD98 down-regulation | Vacuolation score | |||||
|---|---|---|---|---|---|---|---|---|
| 2.5 μM | 10 μM | 40 μM | 2.5 μM | 10 μM | 40 μM | |||
| 3 | 2.1 | [2.0, 2.2] | 42 | 66 | n.d. | ++ | +++ | n.d. |
| 29 | 12.9 | [11.9, 14.0] | n.d. | 3 | -8 | 0 | 0 | 0 |
| 30 | 12.8 | [11.7, 14.0] | n.d. | -9 | 0 | 0 | 0 | 0 |
| 31 | 25.0 | [18.1, 34.4] | n.d. | 3 | 0 | n.d. | 0 | 0 |
| 32 | 25.3 | [19.5, 32.9] | n.d. | 5 | 8 | n.d. | 0 | 0 |
