Table 1.
Means and standard deviations of five FOCM/TS measurements for the autism spectrum disorder (ASD) and neurotypical (NT) cohorts from the Integrated Metabolic and Genomic Endeavor (IMAGE) study. Reported p-values were obtained from the two-tailed Welch’s t-test.
| Measurement | ASD Mean ± SD n = 83 |
NT Mean ± SD n = 76 |
p-Value |
|---|---|---|---|
| % DNA methylation | 3.37 ± 0.87 | 4.26 ± 0.90 | <0.001 |
| 8-hydroxyguanosine (pmol/mg DNA) | 89.2 ± 27.9 | 56.7 ± 17.9 | <0.001 |
| glutamylcysteine (μM) | 1.87 ± 0.46 | 2.37 ± 0.59 | <0.001 |
| free cystine/free cysteine | 1.51 ± 0.58 | 1.06 ± 0.35 | <0.001 |
| % oxidized glutathione | 0.22 ± 0.07 | 0.12 ± 0.04 | <0.001 |