Table 1.

History and clinical data of 4 patients with hereditary angioedema (HAE) who died from laryngeal edema and asphyxiation.

Pt	Gender	Age (years)			HAE attacks			Family history				Treatment received
		At onset of symptoms	At HAE diagnosis	At death	Frequency of previous abdominal and/or peripheral attacks	No. of previous laryngeal attacks	Unnecessary abdominal surgeries before diagnosis?	No. of known relatives with HAE	Relatives experiencing laryngeal edema?	No. of deaths in family resulting from suspected laryngeal edema?	Interval between onset of laryngeal edema and asphyxiation	Home	Emergency services / Hospital	Emergency procedures administered
1	Female	20	50	52	Weekly	>100	3	6	Yes	-	6 h	-	-	-
2	Male	3	7	11	Monthly	3	1	4	Yes	2	3 h	-	Corticosteroids and epinephrine	-
3	Male	8	57	59	Yearly	10	-	3	Yes	-	20 min	-	-	-
4	Male	22	Not previously diagnosed	42	Twice/ month	0	-	5	Yes	5	11 h	Corticosteroids	Epinephrine	Attempted (self-) tracheotomy