Table 1.
Clinical characteristics of patients with NMOSD and MS.
| Clinical characteristics | NMOSD | MS (n=12) |
||
|---|---|---|---|---|
| AQP4 Ab+ (n=25) |
MOG Ab+ (n=8) |
Seronegative (n=16) |
||
| Sex ratio, F (%) | 24(96.0) | 3(37.5) | 11(68.8) | 9(75.0) |
| Age, years, mean (SD) | 44.7(17.0) | 38.3(8.5) | 42.1(11.4) | 37.4(16.0) |
| Disease duration, months, mean (SD) | 18.9(8.8) | 13.3(8.7) | 16.0(10.4) | 22.4(7.3) |
| Site of the lesions, n (%) | ||||
| Optic nerve | 15(60.0) | 3(37.5) | 7(43.6) | 3(25.0) |
| Spinal cord | 25(100.0) | 6(75.0) | 14(87.5) | 7(58.3) |
| Cerebrum | 11(44.0) | 7(87.5) | 8(50.0) | 6(50.0) |
| Brainstem | 13(52.0) | 5(62.5) | 10(62.5) | 4(33.3) |
| EDSS, median (range) | 6.5(2.0-8.5) | 4.3(3.5-7.0) | 6.3(2.5-8.0) | 3.5(2.0-5.0) |
| CSF analysis at attack | ||||
| CSF WBC count, mean (SD), /ul | 19.0(24.3) | 32.0(47.8) | 10.3(15.7) | 9.7(10.7) |
| CSF protein level, mean (SD), mg/dl | 47.8(26.8) | 42.4(16.9) | 39.0(20.0) | 37.4(23.7) |
| CSF IgG index, mean (SD) | 0.6(0.2) | 1.1(1.6) | 0.5(0.1) | 0.6(0.3) |
| Positive oligoclonal bands, n (%) | 15(60.0) | 3(37.5) | 9(56.3) | 8(66.7) |
Continuous variables are shown as the means (SD), and categorical variables are described as percentages. NMOSD, neuromyelitis optica spectrum disorder; AQP4 Ab+, aquaporin-4 antibody positive NMOSD; MOG-Ab+, myelin-oligodendrocyte glycoprotein antibody positive NMOSD; MS, multiple sclerosis; F, female; EDSS, Expanded Disability Status Scale; CSF, cerebrospinal fluid; WBC, white blood cell.